O Amfetaminima

Pitanje:

Zanima me kako zapravo djeluju u organizmu, ne efekt toliko koliko samo djelovanje - na koji element u tijelu, na koji nacin i sl. Znam da se uzima kad se želi biti jaci (treninzi, takmičenja), kad treba odagnati umor (vožnja auta/kamiona i sl), a efekt je i da se gubi na apetitu. Zanima me kako se postižu ti efekti - da li tako da blokira te impulse u mozgu ili jednostavno ubrzava metabolizam, dakle da li pospješuje procese u organizmu da tijelo toliko brze radi ili zapravo samo blokira efekte umora da ne stignu do mozga... i ostale detalje...Ima li tko kakve informacije u tom pogledu?

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Odgovor: 

Kratak izvod iz: 

Waslick B, Greenhill LL. Psychostimulants. In: Lieberman, Tasman: Psyychiatric Drugs, WB Saunders, Philadelphia, 2000. ISBN 0-7216-5884-9 p. 168-192:

The stimulant medications are sometimes known as "sympathomimetic amines" or noncatecholamine sympathomimetics" because when they are administred to humans and animals, they produce many of the central and periphereal manifestations of sympathetic nervous system stimulation.
...
Amphetamine, chemically known as alfa-methylphenethylamine, is available in both d- amphetamine and l-amphetamine forms.
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Mechanism of Action: 
... Primarily, the medications cause a displacement of biogenic amines (norepinephrine, epinephrine, and dopamine) from storage sites in the neuron terminal into the synaptic claft, leading to enhanced biologic activiti of the neurotransmiters. The stimulants probably also inhibit the reuptake of the neurotransmitter into the neural terminal, thus prolonging biologic effects. They may inhibit monoamine oxidase metabolism of the neurotransmitter and may interact directly with presynaptic or postsinaptic receptors. 

... i tako dalje, nadam se da imaš dovoljno znanja iz biokemije da bi ti ovo bilo jasno. Pitanje je bilo izrazito stručno, pa je takav i odgovor. 

Inače, amfetamini su kontrolirane supstance.